Here are the opening lines for Week 4, courtesy of BetOnline.ag.
The top games are Michigan/Nebraska, Illinois/Indiana and Auburn/Oklahoma.
College Football Week 4 lines are subject to change. Here’s the direct link to real-time spreads: https://www.betonline.ag/sportsbook/football/ncaa.
Lines involving FCS teams are usually posted later in the week.
Week 4 College Football Lines
Thursday, September 18, 2025
- Rice (-4½) at Charlotte
Friday, September 19, 2025
- Tulsa at Oklahoma State (-13½)
- Iowa (-2) at Rutgers
Saturday, September 20, 2025
- Syracuse at Clemson (-17)
- Texas Tech at Utah (-4)
- Arkansas (-6) at Memphis
- Maryland at Wisconsin (-7)
- SMU at TCU (-6½)
- Bowling Green at Louisville (-27)
- UNLV (-4) at Miami (OH)
- North Texas at Army (-2½)
- UAB at Tennessee (-38)
- Oregon State at Oregon (-35)
- Purdue at Notre Dame (-26½)
- Kent State at Florida State (-43½)
- Auburn at Oklahoma (-6½)
- Tulane at Ole Miss (-12½)
- Michigan (-1) at Nebraska
- North Carolina at UCF (-6½)
- Ball State at UConn (-20½)
- James Madison (-10½) at Liberty
- Louisiana (-3) at Eastern Michigan
- Troy at Buffalo (-7)
- Toledo (-13½) at Western Michigan
- NC State at Duke (-3)
- Northern Illinois at Mississippi State (-21½)
- Temple at Georgia Tech (-24)
- West Virginia at Kansas (-13)
- Delaware at Florida International (-4½)
- Arkansas State (-7) at Kennesaw State
- South Carolina at Missouri (-12)
- Marshall (-3) at Middle Tennessee
- Nevada at Western Kentucky (-11½)
- Boise State (-8½) at Air Force
- Coastal Carolina at South Alabama (-14½)
- Florida at Miami (-9)
- Illinois at Indiana (-5)
- Georgia State at Vanderbilt (-27)
- Washington (-19½) at Washington State
- Stanford at Virginia (-15)
- Arizona State at Baylor (-1½)
- BYU (-7) at East Carolina
- Southern Miss at Louisiana Tech (-1½)
- Sam Houston at Texas (-40½)
- UL Monroe at UTEP (-5)
- UTSA (-4½) at Colorado State
- Wyoming at Colorado (-13½)
- California (-13) at San Diego State
- Michigan State at USC (-16½)
- Fresno State (-3½) at Hawai’i
