Week 5 of the college football season arrives with conference races heating up and three ranked-on-ranked matchups highlighting a loaded Saturday slate.
Ohio State heads to Iowa as a two-touchdown favorite, Alabama visits Mississippi State for an SEC showdown, and Florida travels to Missouri in another Top 25 battle. Elsewhere, several heavyweights face tricky road tests as the calendar flips to October and the margin for error begins to shrink.
Here’s a look at the complete Week 5 college football betting board, with the latest point spreads from BetOnline Sports & Casino.
Week 5 Football Lines
Thursday, October 1
- Western Kentucky at New Mexico State (-1)
- North Texas at Tulsa (-2.5)
Friday, October 2
- Pittsburgh at Virginia Tech (-4.5)
- Liberty at Delaware (+7)
- Penn State at Northwestern (+3)
Saturday, October 3
- Vanderbilt at Georgia (-24.5)
- Notre Dame at North Carolina (+21.5)
- Miami at Clemson (+17)
- Alabama at Mississippi State (+6)
- Michigan at Minnesota (+6.5)
- Boston College at SMU (-20.5)
- UCF at Houston (-11)
- Middle Tennessee at Kansas (-19.5)
- West Virginia at Iowa State (-2)
- Stanford at Wake Forest (-13)
- Syracuse at UConn (+5.5)
- Navy at Air Force (-2.5)
- Michigan State at Wisconsin (-10)
- Western Michigan at Buffalo (+15.5)
- Toledo at Ball State (+18.5)
- Ohio State at Iowa (+14)
- Auburn at Tennessee (-7.5)
- Louisville at NC State (+6)
- Florida at Missouri (+4)
- California at UNLV (-2)
- Virginia at Florida State (+2.5)
- Memphis at Charlotte (+21.5)
- Wyoming at North Dakota State (-20)
- Akron at Central Michigan (-6.5)
- Eastern Michigan at Massachusetts (-5.5)
- Ohio at Kent State (+5.5)
- Bowling Green at Miami (OH) (-14.5)
- Old Dominion at Georgia State (+1.5)
- Marshall at James Madison (-16.5)
- Maryland at Nebraska (-13.5)
- UTEP at New Mexico (-21.5)
- Kentucky at South Carolina (-3.5)
- Purdue at Illinois (-10)
- Oregon State at Colorado State (+4.5)
- BYU at TCU (+6.5)
- Arkansas at Texas A&M (-14)
- UTSA at Rice (+10.5)
- Georgia Southern at Coastal Carolina (PK)
- UL Monroe at South Alabama (-14)
- Texas Tech at Colorado (+14.5)
- Washington at USC (-9)
- Utah State at Boise State (-21)
- Temple at South Florida (-5.5)
- Army at Louisiana Tech (+3.5)
- Indiana at Rutgers (+23.5)
- Arkansas State at Louisiana (-6)
- Fresno State at Washington State (+1)
- Baylor at Arizona State (-3.5)
- Texas State at San Diego State (+4)
- Cincinnati at Arizona (-7.5)
- San José State at Hawai’i (-3)
