Eagles open as big favorites over Cowboys

The complete 2025 NFL schedule will be released later this week, but the leaks have begun.

The Super Bowl champion Philadelphia Eagles will kick off the 2025 NFL regular season on Thursday, September 4, against the Dallas Cowboys.

🚨 EAGLES VS. COWBOYS TO KICK OFF THE 2025 SEASON 🚨#Kickoff2025 pic.twitter.com/PEHaVYvlxB

— NFL (@NFL) May 12, 2025

BetOnline.ag set the line for the NFC East divisional matchup at a full touchdown. The non-champs have taken two of the past three NFL openers (Lions 2023, Bills 2022).

2025 NFL Kickoff Game (Sept. 4)

Dallas Cowboys             +7

Philadelphia Eagles       -7

Over/Under                    46.5

NFL weekly game odds are subject to change and will be updated in real-time on this page: https://www.betonline.ag/sportsbook/football/nfl