Week 2 College Football Odds & Betting Lines 2025

Oklahoma hosting Michigan headlines college football’s Week 2 slate with the Sooners opening as a 4.5 point favorite.

After a dramatic win at Clemson, LSU gets a breather at home with the Tigers hosting Louisiana Tech.

College Football Week 2 lines are subject to change. Here’s the direct link to real-time spreads: https://www.betonline.ag/sportsbook/football/ncaa.

***Note: FBS vs FCS game lines don’t get posted until later in the week.

Week 2 College Football Lines

Friday, September 5, 2025

• James Madison at Louisville (-15)

• Northern Illinois at Maryland (-16½)

Saturday, September 6, 2025

• San José State at Texas (-36)

• Florida International at Penn State (-42)

• Illinois (-2½) at Duke

• Baylor at SMU (-3)

• Kennesaw State at Indiana (-35½)

• Iowa at Iowa State (-3½)

• Kent State at Texas Tech (-49)

• Virginia at NC State (-3)

• Central Michigan at Pittsburgh (-21½)

• UConn at Syracuse (-7½)

• Liberty (-6½) at Jacksonville State

• Utah State at Texas A&M (-29½)

• Troy at Clemson (-32)

• Oklahoma State at Oregon (-28)

• Ole Miss (-9½) at Kentucky

• Kansas at Missouri (-7)

• Miami (OH) at Rutgers (-14)

• Fresno State at Oregon State (-2½)

• Bowling Green at Cincinnati (-18)

• Texas State at UTSA (-6)

• Delaware at Colorado (-23½)

• UAB at Navy (-21)

• North Texas at Western Michigan

• Middle Tennessee at Wisconsin (-28)

• West Virginia (-3) at Ohio

• South Florida at Florida (-19)

• Arkansas State at Arkansas (-21½)

• Missouri State at Marshall (-10)

• Army at Kansas State (-15)

• North Carolina at Charlotte

• Houston (-13½) at Rice

• Memphis (-14) at Georgia State

• Tulane (-10½) at South Alabama

• Western Kentucky at Toledo (-5½)

• Louisiana Tech at LSU (-37½)

• Arizona State (-7) at Mississippi State

• Michigan at Oklahoma (-4½)

• Ball State at Auburn (-43½)

• Vanderbilt at Virginia Tech (currently OTB)

• Akron at Nebraska (-34)

• Georgia Southern at USC (-28)

• Boston College at Michigan State (-3)

• UL Monroe at Alabama (-37½)

• UCLA (-2) at UNLV

• Tulsa (-2½) at New Mexico State

• San Diego State at Washington State (-3)

• Stanford at BYU (-18½)

• Sam Houston at Hawai’i (-9½)