Oklahoma hosting Michigan headlines college football’s Week 2 slate with the Sooners opening as a 4.5 point favorite.
After a dramatic win at Clemson, LSU gets a breather at home with the Tigers hosting Louisiana Tech.
College Football Week 2 lines are subject to change. Here’s the direct link to real-time spreads: https://www.betonline.ag/sportsbook/football/ncaa.
***Note: FBS vs FCS game lines don’t get posted until later in the week.
Week 2 College Football Lines
Friday, September 5, 2025
- James Madison at Louisville (-15)
- Northern Illinois at Maryland (-16½)
Saturday, September 6, 2025
- San José State at Texas (-36)
- Florida International at Penn State (-42)
- Illinois (-2½) at Duke
- Baylor at SMU (-3)
- Kennesaw State at Indiana (-35½)
- Iowa at Iowa State (-3½)
- Kent State at Texas Tech (-49)
- Virginia at NC State (-3)
- Central Michigan at Pittsburgh (-21½)
- UConn at Syracuse (-7½)
- Liberty (-6½) at Jacksonville State
- Utah State at Texas A&M (-29½)
- Troy at Clemson (-32)
- Oklahoma State at Oregon (-28)
- Ole Miss (-9½) at Kentucky
- Kansas at Missouri (-7)
- Miami (OH) at Rutgers (-14)
- Fresno State at Oregon State (-2½)
- Bowling Green at Cincinnati (-18)
- Texas State at UTSA (-6)
- Delaware at Colorado (-23½)
- UAB at Navy (-21)
- North Texas at Western Michigan
- Middle Tennessee at Wisconsin (-28)
- West Virginia (-3) at Ohio
- South Florida at Florida (-19)
- Arkansas State at Arkansas (-21½)
- Missouri State at Marshall (-10)
- Army at Kansas State (-15)
- North Carolina at Charlotte
- Houston (-13½) at Rice
- Memphis (-14) at Georgia State
- Tulane (-10½) at South Alabama
- Western Kentucky at Toledo (-5½)
- Louisiana Tech at LSU (-37½)
- Arizona State (-7) at Mississippi State
- Michigan at Oklahoma (-4½)
- Ball State at Auburn (-43½)
- Vanderbilt at Virginia Tech (currently OTB)
- Akron at Nebraska (-34)
- Georgia Southern at USC (-28)
- Boston College at Michigan State (-3)
- UL Monroe at Alabama (-37½)
- UCLA (-2) at UNLV
- Tulsa (-2½) at New Mexico State
- San Diego State at Washington State (-3)
- Stanford at BYU (-18½)
- Sam Houston at Hawai’i (-9½)
