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Every Thursday or Friday, BetOnline.ag opens look-ahead lines for the following week. They are taken down on Sunday right before the games start.
Then they are re-opened once the games end.
Sometimes there can be a massive change based on injuries or poor play.
The New Orleans Saints are an incredible 16.5-point underdog at Buffalo Sunday after their embarrassing 44-13 loss at Seattle.
NFL Week 4 spreads are subject to change. Here’s the direct link to those odds: https://www.betonline.ag/sportsbook/football/nfl.
NFL Week 4 Lines
Thursday, September 25, 2025
- Seattle Seahawks at Arizona Cardinals (-1.5)
- Lookahead line was –2.5
Sunday, September 28, 2025
- Minnesota Vikings (-1.5) at Pittsburgh Steelers
- Look-ahead line was Steelers -1.
- Washington Commanders (-3) at Atlanta Falcons
- Look-ahead line was -1.
- New Orleans Saints at Buffalo Bills (-16.5)
- Look-ahead line was –15.5
- Philadelphia Eagles (-3) at Tampa Bay Buccaneers
- Carolina Panthers at New England Patriots (-4)
- Look-ahead line was –5.5
- Cleveland Browns at Detroit Lions (-8.5)
- Look-ahead line was -10.
- Tennessee Titans at Houston Texans (-7)
- Los Angeles Chargers (-6) at New York Giants
- Jacksonville Jaguars at San Francisco 49ers (-3.5)
- Indianapolis Colts at Los Angeles Rams (-4)
- Look-ahead line was -5.
- Chicago Bears at Las Vegas Raiders (-1.5)
- Look-ahead line was -2.5.
- Baltimore Ravens (-3) at Kansas City Chiefs
- Green Bay Packers (-6) at Dallas Cowboys
- Look-ahead line was -5.
Monday, September 29, 2025
- New York Jets at Miami Dolphins (-2.5)
- Cincinnati Bengals at Denver Broncos (-7.5)
- Look-ahead line was -6.5.
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