Saints underdogs at Carolina as Week 10 NFL odds drop

Despite being on a bye, it was a great week of football for the Philadelphia Eagles. They sat home, ate bon bons and watched both Green Bay and Detroit lose at home.

And on Monday morning, the Buffalo Bills will likely once again be the Super Bowl favorites after beating the Kansas City Chiefs 28-21 in a game that did not feel that close.

Oh also, the Bears and Jags have to be the worst 5-3 teams ever. Ok, recency bias.

NFL Week 10 spreads are subject to change. Here’s the direct link to those odds: https://www.betonline.ag/sportsbook/football/nfl.

NFL Week 10 Lines

Thursday, November 6, 2025

• Las Vegas Raiders at Denver Broncos (-10)

Sunday, Nov 9, 2025

• Atlanta Falcons at Indianapolis Colts (-6)
  • Note: Lookahead line opened Colts -7.

• New York Giants at Chicago Bears (-3½)

• Buffalo Bills at Miami Dolphins (+8½)

• Baltimore Ravens at Minnesota Vikings (+3½)
  • Note: Lookahead line opened Vikings +4½.

• Cleveland Browns at New York Jets (-2½)

• New England Patriots at Tampa Bay Buccaneers (-2½)

• New Orleans Saints at Carolina Panthers (-4½)
  • Note: Lookahead line opened Panthers -3½.

• Jacksonville Jaguars at Houston Texans (-3)
  • Note: Lookahead line opened Texans -3. Uncertainty of CJ Stroud’s status probably pushed this line down. 

• Arizona Cardinals at Seattle Seahawks (-6)

• Los Angeles Rams at San Francisco 49ers (+3)

• Detroit Lions at Washington Commanders (+3)

• Pittsburgh Steelers at Los Angeles Chargers (-3)
  • Note: Lookahead line opened Chargers -4½.

Monday, Nov 10, 2025

• Philadelphia Eagles at Green Bay Packers (-2½)