College Football Week 4 Opening Lines: Michigan vs. Nebraska, Auburn vs. Oklahoma, Illinois vs. Indiana

Here are the opening lines for Week 4, courtesy of BetOnline.ag.

The top games are Michigan/Nebraska, Illinois/Indiana and Auburn/Oklahoma.

College Football Week 4 lines are subject to change. Here’s the direct link to real-time spreads: https://www.betonline.ag/sportsbook/football/ncaa.

Lines involving FCS teams are usually posted later in the week.

Week 4 College Football Lines

Thursday, September 18, 2025

• Rice (-4½) at Charlotte

Friday, September 19, 2025

• Tulsa at Oklahoma State (-13½)

• Iowa (-2) at Rutgers

Saturday, September 20, 2025

• Syracuse at Clemson (-17)

• Texas Tech at Utah (-4)

• Arkansas (-6) at Memphis

• Maryland at Wisconsin (-7)

• SMU at TCU (-6½)

• Bowling Green at Louisville (-27)

• UNLV (-4) at Miami (OH)

• North Texas at Army (-2½)

• UAB at Tennessee (-38)

• Oregon State at Oregon (-35)

• Purdue at Notre Dame (-26½)

• Kent State at Florida State (-43½)

• Auburn at Oklahoma (-6½)

• Tulane at Ole Miss (-12½)

• Michigan (-1) at Nebraska

• North Carolina at UCF (-6½)

• Ball State at UConn (-20½)

• James Madison (-10½) at Liberty

• Louisiana (-3) at Eastern Michigan

• Troy at Buffalo (-7)

• Toledo (-13½) at Western Michigan

• NC State at Duke (-3)

• Northern Illinois at Mississippi State (-21½)

• Temple at Georgia Tech (-24)

• West Virginia at Kansas (-13)

• Delaware at Florida International (-4½)

• Arkansas State (-7) at Kennesaw State

• South Carolina at Missouri (-12)

• Marshall (-3) at Middle Tennessee

• Nevada at Western Kentucky (-11½)

• Boise State (-8½) at Air Force

• Coastal Carolina at South Alabama (-14½)

• Florida at Miami (-9)

• Illinois at Indiana (-5)

• Georgia State at Vanderbilt (-27)

• Washington (-19½) at Washington State

• Stanford at Virginia (-15)

• Arizona State at Baylor (-1½)

• BYU (-7) at East Carolina

• Southern Miss at Louisiana Tech (-1½)

• Sam Houston at Texas (-40½)

• UL Monroe at UTEP (-5)

• UTSA (-4½) at Colorado State

• Wyoming at Colorado (-13½)

• California (-13) at San Diego State

• Michigan State at USC (-16½)

• Fresno State (-3½) at Hawai’i