Brad Penner-Imagn Images
By Matt Moscona
The New Orleans Saints are 0-4 after their loss Sunday at Buffalo. Oddsmakers think Kellen Moore has a great shot for his first career win next Sunday at home.
The Giants are a slight one-point favorite against the Saints. New Orleans quarterback Spencer Rattler is also seeking his first win after an 0-10 start to his career.
There are just two remaining undefeated teams in the National Football League, and those teams (Bills and Eagles) are the two Super Bowl favorites.
Two lines for Week 5 are off the board due to quarterback situations. Lamar Jackson is dealing with a hamstring injury and Jayden Daniels’ return status remains uncertain.
Below you’ll find the opening lines for Week 5.
NFL Week 5 spreads are subject to change. Here’s the direct link to those odds: https://www.betonline.ag/sportsbook/football/nfl.
NFL Week 5 Lines
Thursday, October 2, 2025
- San Francisco 49ers at Los Angeles Rams (-3.5)
Sunday, October 5, 2025
- Minnesota Vikings (-4) vs. Cleveland Browns
- Miami Dolphins at Carolina Panthers (PK)
- Dallas Cowboys (-1.5) at New York Jets
- Las Vegas Raiders at Indianapolis Colts (-6.5)
- Denver Broncos at Philadelphia Eagles (-5.5)
- New York Giants (-1) at New Orleans Saints
- Houston Texans at Baltimore Ravens (OTB)
- Tennessee Titans at Arizona Cardinals (-9)
(Lookahead line was –8)
- Tampa Bay Buccaneers at Seattle Seahawks (-3)
(Lookahead line was –2)
- Detroit Lions (-8.5) at Cincinnati Bengals
(Lookahead line was –7.5)
- Washington Commanders at Los Angeles Chargers (OTB)
- New England Patriots at Buffalo Bills (-9)
(Lookahead line was –10)
Monday, October 6, 2025
- Kansas City Chiefs (-3) at Jacksonville Jaguars
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