NFL Week 16 lines show heavy movement, Saints open as home favorites vs Jets

The New Orleans Saints have won consecutive games and the oddsmakers think the streak will continue. The Saints are a four-point home favorite over the Jets Sunday.

Week 16 is highlighted by an awesome Thursday night matchup with the Seattle Seahawks hosting the Los Angeles Rams. There are two other games pitting teams at the top of their division with Chicago hosting Green Bay and Carolina hosting Tampa Bay.

If there’s a spread movement of one point or more compared to the lookahead lines that were released earlier this week, it is noted beneath the current spread.

There was more line movement from the lookahead lines than any other week this season.

NFL Week 16 spreads are subject to change. Here’s the direct link to those odds: https://www.betonline.ag/sportsbook/football/nfl.

NFL Week 16 Lines

Thursday, December 17, 2025

• Los Angeles Rams at Seattle Seahawks (-1)

Saturday, December 20, 2025

• Philadelphia Eagles at Washington Commanders (+5½)

• Green Bay Packers at Chicago Bears (+3)

Sunday, December 21, 2025

• Buffalo Bills at Cleveland Browns (+10)
  • Lookahead line was Cleveland +9.

• Los Angeles Chargers at Dallas Cowboys (-1½)

• Kansas City Chiefs at Tennessee Titans (+4½)
  • Lookahead line was Tennessee +11½. Mahomes injury moved line seven points.

• Cincinnati Bengals at Miami Dolphins (-1)
  • Lookahead line was a pick’em.

• New York Jets at New Orleans Saints (-4)
  • Lookahead line opened New Orleans -3.

• Minnesota Vikings at New York Giants (+1½)

• Tampa Bay Buccaneers at Carolina Panthers (+2½)

• Jacksonville Jaguars at Denver Broncos (-2½)

• Atlanta Falcons at Arizona Cardinals (+1½)
  • Lookahead line was Arizona -1. We now have a new favorite.

• Pittsburgh Steelers at Detroit Lions (-6½)

• Las Vegas Raiders at Houston Texans (-14)
  • Lookahead line was Houston -12½.

• New England Patriots at Baltimore Ravens (-2½)
  • Lookahead line was Baltimore -1.

Monday, December 22, 2025

• San Francisco 49ers at Indianapolis Colts (+5½)
  • Lookahead line was Indianapolis +½6½.