Week 7 College Football Odds: LSU Favored Big Over USC

By Matt Moscona

LSU had a week off to get healthy and get their offense going after a loss at Ole Miss. The oddsmakers think the time will be well spent, favoring the Tiger by 9.5 points over South Carolina.

Can Arch Manning and the Longhorns bounce back from another brutal loss in the Red River Rivalry at the Cotton Bowl this week? 

This is one of the tightest spreads we’ve seen between Texas and Oklahoma in quite some time.

Another pivotal matchup in Week 7 is Indiana heading to Oregon to take on Dante Moore and the undefeated Ducks.

The Georgia-Auburn bout should be one to watch as well, with the Bulldogs opening as field-goalish favorites.

Below are the opening lines for Week 7, courtesy of BetOnline.ag.

College football Week 7 lines are subject to change. Here’s the direct link to real-time spreads: https://www.betonline.ag/sportsbook/football/ncaa.

Week 7 College Football Lines 

Wednesday, October 8, 2025 

• Missouri State at Middle Tennessee (+2.5)

• Liberty at UTEP (+2)

Thursday, October 9, 2025 

• Louisiana Tech at Kennesaw State (+7)

• East Carolina at Tulane (-6.5)

• Jacksonville State at Sam Houston (+9.5)

• Southern Miss at Georgia Southern (+2.5)

Friday, October 10, 2025 

• South Florida at North Texas (-2.5)

• Rutgers at Washington (-10.5)

• Fresno State at Colorado State (+6.5)

Saturday, October 11, 2025 

• Florida at Texas A&M (-7.5)

• Georgia at Auburn (+3.5)

• Alabama at Missouri (+5)

• Ohio State at Illinois (+14.5)

• Pittsburgh at Florida State (-9.5)

• UCLA at Michigan State (-7.5)

• Stanford at SMU (-17.5)

• UCF at Cincinnati (-10.5)

• Houston at Oklahoma State (+14)

• Louisiana at James Madison (-18)

• Charlotte at Army (-17.5)

• Miami (OH) at Akron (+9.5)

• Toledo at Bowling Green (+8.5)

• Washington State at Ole Miss (-32)

• Northern Illinois at Eastern Michigan (PK)

• Massachusetts at Kent State (-2.5)

• Indiana at Oregon (-9.5)

• Oklahoma vs. Texas (-3)

• Northwestern at Penn State (-21.5)

• Iowa State at Colorado (-5)

• Virginia Tech at Georgia Tech (-13)

• NC State at Notre Dame (-21.5)

• Nebraska at Maryland (+4.5)

• Wake Forest at Oregon State (+1.5)

• TCU at Kansas State (+1)

• Air Force at UNLV (-7)

• App State at Georgia State (+3.5)

• Old Dominion at Marshall (+13)

• Ball State at Western Michigan (-9.5)

• Navy at Temple (+8)

• Arkansas at Tennessee (-13)

• UAB at Florida Atlantic (-5)

• Iowa at Wisconsin (+3)

• San Jose State at Wyoming (PK)

• UL Monroe at Coastal Carolina (+2)

• Kansas at Texas Tech (-14)

• Michigan at USC (-2.5)

• Purdue at Minnesota (-10)

• Clemson at Boston College (+13)

• Rice at UTSA (-13.5)

• BYU at Arizona (+1.5)

• Troy at Texas State (-10.5)

• South Carolina at LSU (-9.5) 

• New Mexico at Boise State (-15.5)

• Arizona State at Utah (-7)

• San Diego State at Nevada (+6)

• Utah State at Hawaii (-2.5)