Week 5 Odds: LSU opens as small favorite at Ole Miss

Week 5 has some massive games. Oregon at Penn State, Georgia at Alabama and LSU at Ole Miss are the top games that will have significant CFP implications.

At 4-0 and ranked No. 4, LSU is a 1.5-point favorite at Ole Miss. The Rebels are ranked No. 13 and are coming off an impressive 45-10 win over Tulane.

Below are the opening lines for Week 5, courtesy of BetOnline.ag.

College football Week 5 lines are subject to change. Here’s the direct link to real-time spreads: https://www.betonline.ag/sportsbook/football/ncaa.

Week 5 College Football Lines 

Thursday, September 25, 2025

• Army at East Carolina (-3.5)

Friday, September 26, 2025 

• Florida State (-7) at Virginia

• TCU at Arizona State (-3)

• Houston (-12.5) at Oregon State

Saturday, September 27, 2025 

• Ohio State (-11.5) at Washington

• USC (-1.5) at Illinois

• Indiana (-7) at Iowa

• UCLA at Northwestern (-6)

• Memphis (-13.5) at Florida Atlantic

• Tulane (-13.5) at Tulsa

• Georgia Tech (-14) at Wake Forest

• Notre Dame (-6) at Arkansas

• Rutgers at Minnesota (-6)

• Duke (-4.5) at Syracuse

• Louisville (-3) at Pittsburgh

• Cincinnati at Kansas (-6)

• UCF at Kansas State (-6.5)

• South Alabama at North Texas (-11)

• Bowling Green at Ohio (-10.5)

• Utah State at Vanderbilt (-22.5)

• Eastern Michigan at Central Michigan (-6)

• Georgia Southern at James Madison (-16.5)

• Arkansas State at UL Monroe (-2.5)

• LSU (-1.5) at Ole Miss 

• Auburn at Texas A&M (-6.5)

• Utah (-10) at West Virginia

• California at Boston College (-6.5)

• Baylor (-20.5) at Oklahoma State

• UConn (-3) at Buffalo

• San Diego State (-3) at Northern Illinois

• Rice at Navy (-14.5)

• Akron at Toledo (21.5)

• New Mexico State at New Mexico (-13)

• Hawai’i at Air Force (-5.5)

• Tennessee (-10) at Mississippi State

• Middle Tennessee at Kennesaw State (-6.5)

• Liberty at Old Dominion (-14)

• Arizona at Iowa State (-7)

• Virginia Tech at NC State (-8.5)

• Jacksonville State at Southern Miss (-3.5)

• Western Kentucky (-5.5) at Missouri State

• Oregon at Penn State (-3.5)

• Alabama at Georgia (-3.5)

• Massachusetts at Missouri (-42.5)

• Washington State at Colorado State (-3.5)

• San José State at Stanford (-1.5)

• Appalachian State at Boise State (-15)

• Kentucky at South Carolina (-7)

• Marshall at Louisiana (-3)

• Louisiana Tech (-3) at UTEP

• BYU (-6.5) at Colorado