Week 5 has some massive games. Oregon at Penn State, Georgia at Alabama and LSU at Ole Miss are the top games that will have significant CFP implications.
At 4-0 and ranked No. 4, LSU is a 1.5-point favorite at Ole Miss. The Rebels are ranked No. 13 and are coming off an impressive 45-10 win over Tulane.
Below are the opening lines for Week 5, courtesy of BetOnline.ag.
College football Week 5 lines are subject to change. Here’s the direct link to real-time spreads: https://www.betonline.ag/sportsbook/football/ncaa.
Week 5 College Football Lines
Thursday, September 25, 2025
- Army at East Carolina (-3.5)
Friday, September 26, 2025
- Florida State (-7) at Virginia
- TCU at Arizona State (-3)
- Houston (-12.5) at Oregon State
Saturday, September 27, 2025
- Ohio State (-11.5) at Washington
- USC (-1.5) at Illinois
- Indiana (-7) at Iowa
- UCLA at Northwestern (-6)
- Memphis (-13.5) at Florida Atlantic
- Tulane (-13.5) at Tulsa
- Georgia Tech (-14) at Wake Forest
- Notre Dame (-6) at Arkansas
- Rutgers at Minnesota (-6)
- Duke (-4.5) at Syracuse
- Louisville (-3) at Pittsburgh
- Cincinnati at Kansas (-6)
- UCF at Kansas State (-6.5)
- South Alabama at North Texas (-11)
- Bowling Green at Ohio (-10.5)
- Utah State at Vanderbilt (-22.5)
- Eastern Michigan at Central Michigan (-6)
- Georgia Southern at James Madison (-16.5)
- Arkansas State at UL Monroe (-2.5)
- LSU (-1.5) at Ole Miss
- Auburn at Texas A&M (-6.5)
- Utah (-10) at West Virginia
- California at Boston College (-6.5)
- Baylor (-20.5) at Oklahoma State
- UConn (-3) at Buffalo
- San Diego State (-3) at Northern Illinois
- Rice at Navy (-14.5)
- Akron at Toledo (21.5)
- New Mexico State at New Mexico (-13)
- Hawai’i at Air Force (-5.5)
- Tennessee (-10) at Mississippi State
- Middle Tennessee at Kennesaw State (-6.5)
- Liberty at Old Dominion (-14)
- Arizona at Iowa State (-7)
- Virginia Tech at NC State (-8.5)
- Jacksonville State at Southern Miss (-3.5)
- Western Kentucky (-5.5) at Missouri State
- Oregon at Penn State (-3.5)
- Alabama at Georgia (-3.5)
- Massachusetts at Missouri (-42.5)
- Washington State at Colorado State (-3.5)
- San José State at Stanford (-1.5)
- Appalachian State at Boise State (-15)
- Kentucky at South Carolina (-7)
- Marshall at Louisiana (-3)
- Louisiana Tech (-3) at UTEP
- BYU (-6.5) at Colorado
