The Week 11 slate in college football features Frank Wilson’s debut as LSU interim head coach when the Tigers head to Tuscaloosa to take on No. 4 Alabama. If the Tigers pull off the upset, they will have to do it as a double-digit underdog.
Alabama opens as a 10.5-point favorite over LSU.
Below are the opening lines for Week 11, courtesy of BetOnline.ag.
College football Week 11 lines are subject to change. Here’s the direct link to real-time spreads: https://www.betonline.ag/sportsbook/football/ncaa.
Week 11 College Football Lines
Tuesday, November 4, 2025
- Massachusetts at Akron (-10.5)
- Miami (OH) at Ohio (-3.5)
Wednesday, November 5, 2025
- Kent State at Ball State (-2.5)
- Northern Illinois at Toledo (-14)
Thursday, November 6, 2025
- Georgia Southern at Appalachian State (-6.5)
- UTSA at South Florida (-13.5)
Friday, November 7, 2025
- Houston at UCF (-1)
- Northwestern at USC (-15)
- Tulane at Memphis (-6.5)
Saturday, November 8, 2025
- Indiana at Penn State (+13.5)
- Oregon at Iowa (+5.5)
- Nebraska at UCLA (+2)
- Washington at Wisconsin (+10.5)
- Georgia at Mississippi State (+7.5)
- BYU at Texas Tech (-10.5)
- SMU at Boston College (+12)
- Colorado at West Virginia (-6)
- James Madison at Marshall (+13)
- Southern Miss at Arkansas State (+5.5)
- Temple at Army (-6.5)
- Ohio State at Purdue (+28.5)
- Missouri State at Liberty (-8)
- Bowling Green at Eastern Michigan (-1.5)
- UAB at Rice (-3.5)
- Maryland at Rutgers (-1)
- Louisiana Tech at Delaware (+4)
- Florida International at Middle Tennessee (+1)
- Jacksonville State at UTEP (+1)
- Charlotte at East Carolina (-28.5)
- Tulsa at Florida Atlantic (-4.5)
- Texas A&M at Missouri (+6.5)
- Duke at UConn (+8.5)
- Kansas at Arizona (-6.5)
- Iowa State at TCU (-6.5)
- Auburn at Vanderbilt (-7)
- Kennesaw State at New Mexico State (+6.5)
- Syracuse at Miami (-28)
- Georgia State at Coastal Carolina (-7.5)
- Stanford at North Carolina (-9)
- Texas State at Louisiana (+2.5)
- Air Force at San Jose State (-3.5)
- Wake Forest at Virginia (-6.5)
- California at Louisville (-18.5)
- Florida State at Clemson (-2)
- LSU at Alabama (-10.5)
- Navy at Notre Dame (-24.5)
- Florida at Kentucky (+3)
- Nevada at Utah State (-10.5)
- UNLV at Colorado State (+5.5)
- Sam Houston at Oregon State (-18.5)
- San Diego State at Hawai’i (+5)
